MRI-Compatible Preclinical PET Scanner

Discover links between molecular mechanisms and functional response

Cubresa's NuPET™ is a revolutionary in-bore PET scanner that inserts into existing MRI instruments to create a powerful and flexible hybrid preclinical in vivo imaging platform that combines the molecular sensitivity of PET with the superior anatomical, structural, and functional information of MRI.

Researchers using simultaneous PET/MRI imaging can measure multiple physiological processes concurrently with exceptional tissue contrast, quantitative accuracy, and study throughput.

NuPET MR-compatible PET scanner

Sequential PET/MRI scanning captures data at different times, making it difficult to analyze important functional relationships when animal physiology can change within minutes. With NuPET's simultaneous scanning, PET and MRI work in unison to capture time-synchronized and highly complementary information previously unattainable – so you can trailblaze a path to new discoveries. Shorter anesthesia duration also helps minimize animal stress and reduce the risk of inducing physiological changes that can affect study quality.


The NuPET Solution

NuPET systems come in three sizes, the NuPET 66, NuPET 100, and NuPET 200, to accommodate a variety of animal models including rodents, rabbits, and non-human primates (NHPs).

The NuPET scanner can be quickly inserted and removed when simultaneous PET/MRI imaging is required. However, should only PET imaging be needed, the NuPET systems can be used as stand-alone scanners. This table-top option ensures that use of the MR is not restricted when only PET scanning is required, offering institutions flexibility and convenience.


  • MR Compatible design and true simultaneous PET/MRI data acquisition
  • Supports powerful small animal gradients in a wide range of MRI systems at various field strengths
  • State of the art PET technology delivers high spatial resolution and sensitivity
  • Automatic PET/MRI co-registration
  • Intuitive acquisition & reconstruction software
  • Rapid setup time and fast removal with no modifications to the MRI system
  • Stand-alone PET imaging option for maximum flexibility and utilization


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Cubresa NuPET MR-compatible PET scanner being inserted into a preclinical MRI bore

Reveal Disease & Therapeutic Mechanisms with Simultaneous Molecular & Functional Imaging

Non-invasively generate 3D images of biochemical processes in live animals with Cubresa’s in-bore NuPET™ Positron Emission Tomography (PET) imaging system for your existing preclinical Magnetic Resonance Imaging (MRI) system. Add precisely registered molecular imaging to high-resolution anatomic imaging with simultaneous PET/MR imaging.

Simulated SPECT image using MOBY mouse phantom

An Easy Addition to Your Small-Animal Preclinical MRI System

Advanced solid-state, chip-based detectors optimized for small-animal subjects preserve important performance parameters such as spatial resolution and sensitivity. With the industry’s most compact footprint, Cubresa’s PET scanner integrates with existing preclinical MRI systems to deliver simultaneous PET/MR imaging without impacting standalone MRI performance.

The NuPET Insert System

Incredibly flexible, the NuPET system can be used in multiple MRIs within a research lab. Completely mobile, the insert can be moved and inserted into various systems as required. This feature enables research groups to share equipment and move NuPET across the lab, down the hall, or to another building. Alternatively, NuPET can also be used as a stand-alone PET imaging system, when simultaneous imaging is not required.

General Information

Perron JR, McIntosh BJ, Leggett S, Palmer VL, Herrera SL, Armstrong K, Stecina K, Martin M. Multi-modal PET-MR imaging of the selective activation of serotonergic neurons in living rodent brains with DREADD technology. Manitoba Poster Competition, Canadian Student Health Research Forum, August 21, 2020.

PDF Summary

Van Elburg D, Shrestha R, and Goertzen AL. Towards a second-generation PET/MR insert with enhanced timing and count rate performance. Physics in Medicine and Biology. 2019 Mar 12. doi:

PET/MRI evaluation of white matter inflammation in a co-morbid rat model of ischemic stroke and Alzheimer’s disease (and others)

Jonathan Thiessen, Ph.D., Director, PET/MRI Program, Lawson Health Research Institute, Assistant Professor, Depts. of Medical Biophysics and Medical Imaging, Western University.

Matthew S. Fox, Ph.D., Preclinical Imaging Physicist, Lawson Health Research Institute Research Associate, Dept. of Physics and Astronomy, Western University By helping to advance hybrid PET/MRI and multi-parametric diagnostic imaging tools, we hope to give new insight into the early biomarkers of disease and improve diagnosis and therapy in patients. Projects at a glance: PET/MRI…