Skip to content

Neuroscience – Receptor Activity

Correlate Brain Chemistry with Brain Activity

Both PET and MRI scanning have been used for neuroimaging1. However, with the advent of simultaneous PET/MR imaging, these complementary techniques allow researchers to better correlate changes in brain chemistry with changes in brain activity.

More Information

Please send me more information.

Parameter maps from PET data overlaid on MRI atlas (upper) and %CBV change from fMRI data by P-value map with P<0.03 (lower).
Parameter maps from PET data overlaid on MRI atlas (upper) and %CBV change from fMRI data by P-value map with P<0.03 (lower).

Simultaneous PET/fMRI Measures Response to a Pharmaceutical Antagonist

A recent study by researchers from Massachusetts General Hospital, MIT, the University of Copenhagen, and Katholieke Universiteit in Leuven employed simultaneous PET/fMRI to measure neurovascular response when administering pharmacologic doses of a receptor agonist while at the same time measuring dopamine D2/D3R occupancy in basal ganglia of non-human primates2.

The results showed strong correlation between neurovascular response and dopamine receptor binding across a wide dynamic range and demonstrate the usefulness of concurrent assessment of hemodynamics and receptor-specific neurotransmission in preclinical and clinical studies.

Schematic illustrating the basic PET/fMRI paradigm.
Schematic illustrating the basic PET/fMRI paradigm.

Recent Development of PET/MRI Capability Enables New Research

Prior to this study, little or no reporting had been done on comparing the functional output measured by fMRI and changes to the neuroreceptor system target by a specific ligand. The authors suppose that this absence of published work is due to the lack of suitable instrumentation such as a combined PET/fMRI system for simultaneous quantitative imaging. PET emission data offers high sensitivity and neurochemical specificity, while fMRI offers high spatio-temporal resolution for changes in neurovascular activity.

In a few short years, simultaneous PET/MRI has become more commonplace. As of 2015, the Whole Brain Atlas3 even gives the viewer the ability to visualize both PET and MRI images of normal anatomy separately as well as together.

Overlaid PET FDG data onto MRI scan shown in the online Whole Brain Atlas.
Overlaid PET FDG data onto MRI scan shown in the online Whole Brain Atlas.

Related

Fox, MS, Palmer VL, Schellenberg G, Matwiy J, King SB, Goertzen AL, Thiessen JD. First Results from an MRI Compatible Small Animal PET Insert Operating in a 3T Clinical PET/MRI. ISMRM 25th Annual Meeting, Honolulu, HI, USA, April 22-27, 2017. http://archive.ismrm.org/2017/1349.html

PDF Summary

Tracking CAR T cell therapies with PET/MRI

Amer Najjar, Ph.D., Assistant Professor, Department of Pediatrics, UT MD Anderson Cancer Center.

The combined Cubresa PET/MRI system has been a crucial tool in advancing our understanding of adoptive cell therapy of brain tumors. These studies exploit the sensitivity of PET to define the spatial distribution of adoptively transferred immune cells and the specificity of MRI to delineate brain tumors and their responses to therapy. Over the last…